7-Amino-5-methyl-5H-dibenzo[b,d]azepin-6(7H)-one → 2-Benzyl-N-(3,5-difluoro-benzyl)-N'-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-malonamide

HRID 2223273Notes

Reaction equation

HRID 2223273 reaction equation
[NH2:1][CH:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][C:3]1=2.[F:19][C:20]1[CH:21]=[C:22]([CH:38]=[C:39]([F:41])[CH:40]=1)[CH2:23][NH:24][C:25](=[O:37])[CH:26]([CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:27](O)=[O:28]>>[CH2:30]([CH:26]([C:27]([NH:1][CH:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][C:3]1=2)=[O:28])[C:25]([NH:24][CH2:23][C:22]1[CH:38]=[C:39]([F:41])[CH:40]=[C:20]([F:19])[CH:21]=1)=[O:37])[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

Participants

3

Reactant 2

HCID 101986267-Amino-5-methyl-5H-dibenzo[b,d]azepin-6(7H)-oneHCID 69282733HCID 69282733, compound

Product 1

HCID 692800842-Benzyl-N-(3,5-difluoro-benzyl)-N'-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-malonamide

Procedure

The title compound, MS: m/e=539.2 (M+H+), was prepared in analogy to example 16 from 7-amino-5-methyl-5H,7H-dibenzo[b,d]azepin-6-one and N-(3,5-difluoro-benzyl)-2-benzyl-malonamic acid.

Sources & evidence

ORD record
ord-40c682e84b644e8084256c888a4294b9
Source dataset
uspto-grants-2008_05
Patent number
US07375099B2

Reaction notes

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