7-Amino-5-methyl-5H-dibenzo[b,d]azepin-6(7H)-one → N-(3,5-Difluoro-benzyl)-N'-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-malonamide

HRID 2223275Notes

Reaction equation

HRID 2223275 reaction equation
[NH2:1][CH:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][C:3]1=2.[F:19][C:20]1[CH:21]=[C:22]([CH:31]=[C:32]([F:34])[CH:33]=1)[CH2:23][NH:24][C:25](=[O:30])[CH2:26][C:27](O)=[O:28]>>[F:19][C:20]1[CH:21]=[C:22]([CH:31]=[C:32]([F:34])[CH:33]=1)[CH2:23][NH:24][C:25](=[O:30])[CH2:26][C:27]([NH:1][CH:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][C:3]1=2)=[O:28]

Participants

3

Reactant 2

HCID 101986267-Amino-5-methyl-5H-dibenzo[b,d]azepin-6(7H)-oneHCID 69280030N-(3,5-Difluoro-benzyl)-malonamic acid

Product 1

HCID 69284210N-(3,5-Difluoro-benzyl)-N'-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-malonamide

Procedure

The title compound, MS: m/e=450.2 (M+H+), was prepared in analogy to example 16 from 7-amino-5-methyl-5H,7H-dibenzo[b,d]azepin-6-one and N-(3,5-difluoro-benzyl)-malonamic acid.

Sources & evidence

ORD record
ord-477f431f32e1479dac2f4809e26b0669
Source dataset
uspto-grants-2008_05
Patent number
US07375099B2

Reaction notes

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