7-Amino-5-methyl-5H-dibenzo[b,d]azepin-6(7H)-one → N-(4-Chloro-benzyl)-2-methyl-N'-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-malonamide

HRID 2223282Notes

Reaction equation

HRID 2223282 reaction equation
[NH2:1][CH:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[C:4]2[CH:15]=[CH:16][CH:17]=[CH:18][C:3]1=2.[CH3:19][CH:20]([C:24]([NH:26][CH2:27][C:28]1[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][CH:29]=1)=[O:25])[C:21](O)=[O:22]>>[Cl:34][C:31]1[CH:32]=[CH:33][C:28]([CH2:27][NH:26][C:24](=[O:25])[CH:20]([CH3:19])[C:21]([NH:1][CH:2]2[C:8](=[O:9])[N:7]([CH3:10])[C:6]3[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=3[C:4]3[CH:15]=[CH:16][CH:17]=[CH:18][C:3]2=3)=[O:22])=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 101986267-Amino-5-methyl-5H-dibenzo[b,d]azepin-6(7H)-oneHCID 69282746HCID 69282746, compound

Product 1

HCID 10095860N-(4-Chloro-benzyl)-2-methyl-N'-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-malonamide

Procedure

The title compound, MS: m/e=462.2 (M+H+), was prepared in analogy to example 16 from 7-amino-5-methyl-5H,7H-dibenzo[b,d]azepin-6-one and 2-methyl-N-(4-chloro-benzyl)-malonamic acid.

Sources & evidence

ORD record
ord-492c5b4b294145709fe2a2c251122220
Source dataset
uspto-grants-2008_05
Patent number
US07375099B2

Reaction notes

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