3-Amino-1-methyl-5-phenyl-1H-benzo[E][1,4]diazepin-2(3H)-one → HCID 69280668, compound

HRID 2223291Notes

Reaction equation

HRID 2223291 reaction equation
[NH2:1][CH:2]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6]2[CH:15]=[CH:16][CH:17]=[CH:18][C:5]=2[N:4]([CH3:19])[C:3]1=[O:20].[CH3:21][CH:22]([C:26]([NH:28][CH2:29][C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[C:32]([O:38][CH3:39])[CH:31]=1)=[O:27])[C:23](O)=[O:24]>>[CH3:39][O:38][C:32]1[CH:31]=[C:30]([CH:35]=[CH:34][C:33]=1[O:36][CH3:37])[CH2:29][NH:28][C:26](=[O:27])[CH:22]([CH3:21])[C:23]([NH:1][CH:2]1[C:3](=[O:20])[N:4]([CH3:19])[C:5]2[CH:18]=[CH:17][CH:16]=[CH:15][C:6]=2[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:8]1)=[O:24]

Participants

3

Reactant 2

HCID 27296813-Amino-1-methyl-5-phenyl-1H-benzo[E][1,4]diazepin-2(3H)-oneHCID 69280721HCID 69280721, compound

Product 1

HCID 69280668HCID 69280668, compound

Procedure

The title compound, MS: m/e=515.3 (M+H+), was prepared in analogy to example 16 from 3-amino-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one and 2-methyl-N-(3,4-dimethoxy-benzyl)-malonamic acid.

Sources & evidence

ORD record
ord-feab8e13a5074e1a99b8c2d89650b4bf
Source dataset
uspto-grants-2008_05
Patent number
US07375099B2

Reaction notes

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