3-Amino-1-methyl-5-phenyl-1H-benzo[E][1,4]diazepin-2(3H)-one → HCID 69280035, compound

HRID 2223292Notes

Reaction equation

HRID 2223292 reaction equation
[NH2:1][CH:2]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6]2[CH:15]=[CH:16][CH:17]=[CH:18][C:5]=2[N:4]([CH3:19])[C:3]1=[O:20].[CH3:21][CH:22]([C:26]([NH:28][CH2:29][C:30]1[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=1)=[O:27])[C:23](O)=[O:24]>>[F:36][C:33]1[CH:34]=[CH:35][C:30]([CH2:29][NH:28][C:26](=[O:27])[CH:22]([CH3:21])[C:23]([NH:1][CH:2]2[C:3](=[O:20])[N:4]([CH3:19])[C:5]3[CH:18]=[CH:17][CH:16]=[CH:15][C:6]=3[C:7]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)=[N:8]2)=[O:24])=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 27296813-Amino-1-methyl-5-phenyl-1H-benzo[E][1,4]diazepin-2(3H)-oneHCID 44541626HCID 44541626, compound

Product 1

HCID 69280035HCID 69280035, compound

Procedure

The title compound, MS: m/e=473.2 (M+H+), was prepared in analogy to example 16 from 3-amino-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one and 2-methyl-N-(4-fluoro-benzyl)-malonamic acid.

Sources & evidence

ORD record
ord-0808310c85b341f0bd66a46b903ec6d8
Source dataset
uspto-grants-2008_05
Patent number
US07375099B2

Reaction notes

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