HCID 59829749, compound → HCID 59715391, compound

Participants

Reaction Steps

To a solution of 2-[2-(5-bromo-benzofuran-7-yl)-ethyl]-3-fluoro-benzoic acid methyl ester (1.5 g, 1.0 equiv) in DMF (16 mL) was added CuCN (0.7 g, 2.0 equiv). The resulting reaction mixture was allowed to heat for 16 hr before additional CuCN (0.7 g, 2.0 equiv) was added. After heating for 6 hr, the reaction mixture was allowed to cool to room temperature, diluted with EtOAc and filtered through celite. The filtrate was washed with saturated aqueous NaHCO3 and water and then dried over MgSO4, filtered, and concentrated. Purification of the residue by column chromatography (SiO2, EtOAc/hexane) gave the desired nitrile (0.6 g, 50%).

Provenance & Evidence