HRID2223339

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID552549

(Trifluoromethyl)trimethylsilane

C4H9F3Si

结构：C=C[C@@]12CCc3cc(OC)ccc3[C@H]1[C@@H](CCCCC=O)C[C@]1(C)[C@@H](O[Si](C)(C)C(C)(C)C)CC[C@H]12

HCID12136519

未命名化合物

PRODUCTS

生成物

结构：C=C[C@@]12CCc3cc(OC)ccc3[C@H]1[C@@H](CCCCC(O)C(F)(F)F)C[C@]1(CO[SiH](C)C)[C@@H](C(C)(C)C)CC[C@@H]21

HCID137331241

未命名化合物

PROCEDURE

实验过程

In the reaction with (trifluoromethyl)-trimethylsilane analogously to instructions 1.1, 900 mg of aldehyde 9a yields 804 mg of alcohol 14a as a colorless foam (GC-MS: m/z theor.: 580, pract.: 580) and a mixture of its diastereomers.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-14e7fa7ae9374003b38d6ccf85c27a40
来源数据集: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07375098B2
来源说明: uspto-grants-2008_05

反应 SMILES

[F:1][C:2]([Si](C)(C)C)([F:4])[F:3].[Si:9]([O:16][C@H:17]1[CH2:22][CH2:21][C@H:20]2[C@@:23]3([CH:43]=[CH2:44])[C@H:32]([C@@H:33]([CH2:35][CH2:36][CH2:37][CH2:38][CH:39]=[O:40])[CH2:34][C@:18]12[CH3:19])[C:31]1[CH:30]=[CH:29][C:28]([O:41][CH3:42])=[CH:27][C:26]=1[CH2:25][CH2:24]3)(C(C)(C)C)([CH3:11])[CH3:10]>>[C:18]([C@H:19]1[CH2:22][CH2:21][C@H:20]2[C@@:23]3([CH:43]=[CH2:44])[C@H:32]([C@@H:33]([CH2:35][CH2:36][CH2:37][CH2:38][CH:39]([OH:40])[C:2]([F:1])([F:3])[F:4])[CH2:34][C@:18]12[CH2:17][O:16][SiH:9]([CH3:10])[CH3:11])[C:31]1[CH:30]=[CH:29][C:28]([O:41][CH3:42])=[CH:27][C:26]=1[CH2:25][CH2:24]3)([CH3:20])([CH3:19])[CH3:17]