(Trifluoromethyl)trimethylsilane → HCID 137331241, compound

HRID 2223339Notes

Reaction equation

HRID 2223339 reaction equation
[F:1][C:2]([Si](C)(C)C)([F:4])[F:3].[Si:9]([O:16][C@H:17]1[CH2:22][CH2:21][C@H:20]2[C@@:23]3([CH:43]=[CH2:44])[C@H:32]([C@@H:33]([CH2:35][CH2:36][CH2:37][CH2:38][CH:39]=[O:40])[CH2:34][C@:18]12[CH3:19])[C:31]1[CH:30]=[CH:29][C:28]([O:41][CH3:42])=[CH:27][C:26]=1[CH2:25][CH2:24]3)(C(C)(C)C)([CH3:11])[CH3:10]>>[C:18]([C@H:19]1[CH2:22][CH2:21][C@H:20]2[C@@:23]3([CH:43]=[CH2:44])[C@H:32]([C@@H:33]([CH2:35][CH2:36][CH2:37][CH2:38][CH:39]([OH:40])[C:2]([F:1])([F:3])[F:4])[CH2:34][C@:18]12[CH2:17][O:16][SiH:9]([CH3:10])[CH3:11])[C:31]1[CH:30]=[CH:29][C:28]([O:41][CH3:42])=[CH:27][C:26]=1[CH2:25][CH2:24]3)([CH3:20])([CH3:19])[CH3:17]

Participants

3

Reactant 2

HCID 552549(Trifluoromethyl)trimethylsilaneHCID 12136519HCID 12136519, compound

Product 1

HCID 137331241HCID 137331241, compound

Procedure

In the reaction with (trifluoromethyl)-trimethylsilane analogously to instructions 1.1, 900 mg of aldehyde 9a yields 804 mg of alcohol 14a as a colorless foam (GC-MS: m/z theor.: 580, pract.: 580) and a mixture of its diastereomers.

Sources & evidence

ORD record
ord-14e7fa7ae9374003b38d6ccf85c27a40
Source dataset
uspto-grants-2008_05
Patent number
US07375098B2

Reaction notes

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