Silane, trimethyl(trifluoroethenyl)- → HCID 131726885, compound

HRID 2223343Notes

Reaction equation

HRID 2223343 reaction equation
[F:1][C:2]([F:9])=[C:3]([F:8])[Si](C)(C)C.[Si:10]([O:17][C@H:18]1[CH2:23][CH2:22][C@H:21]2[C@@:24]3([CH:44]=[CH2:45])[C@H:33]([C@@H:34]([CH2:36][CH2:37][CH2:38][CH2:39][CH:40]=[O:41])[CH2:35][C@:19]12[CH3:20])[C:32]1[CH:31]=[CH:30][C:29]([O:42][CH3:43])=[CH:28][C:27]=1[CH2:26][CH2:25]3)([C:13]([CH3:16])([CH3:15])[CH3:14])([CH3:12])[CH3:11]>>[Si:10]([O:17][C@H:18]1[CH2:23][CH2:22][C@H:21]2[C@@:24]3([CH:44]=[CH2:45])[C@H:33]([C@@H:34]([CH2:36][CH2:37][CH2:38][CH2:39][CH:40]([O:41][Si:10]([CH3:13])([CH3:12])[CH3:11])[C:3]([F:8])=[C:2]([F:9])[F:1])[CH2:35][C@:19]12[CH3:20])[C:32]1[CH:31]=[CH:30][C:29]([O:42][CH3:43])=[CH:28][C:27]=1[CH2:26][CH2:25]3)([C:13]([CH3:16])([CH3:15])[CH3:14])([CH3:11])[CH3:12]

Participants

3

Reactant 2

HCID 11205884Silane, trimethyl(trifluoroethenyl)-HCID 12136519HCID 12136519, compound

Product 1

HCID 131726885HCID 131726885, compound

Procedure

In the reaction with 1,1,2-trifluoro-2-trimethylsilyl ethylene analogously to instructions 1.1, 60 mg of aldehyde 9a yields 77 mg of trimethylsilyl ether 23a as a colorless foam (GC-MS: m/z theor.: 664, pract.: 664) and a mixture of its diastereomers. The latter is used without further purification in the next stage.

Sources & evidence

ORD record
ord-bd4833a20d724afcb7e88c80bf3f206d
Source dataset
uspto-grants-2008_05
Patent number
US07375098B2

Reaction notes

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