Dimethylamine → HCID 12137008, compound

HRID 2223350Notes

Reaction equation

HRID 2223350 reaction equation
[CH3:1][NH:2][CH3:3].C(=O)([O-])[O-].[Na+].[Na+].Cl[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C@H:17]1[CH2:34][C@@:32]2([CH3:33])[C@@H:28]([CH2:29][CH2:30][C@@H:31]2[OH:35])[C@@:27]2([CH:36]=[CH2:37])[C@H:18]1[C:19]1[CH:20]=[CH:21][C:22]([OH:38])=[CH:23][C:24]=1[CH2:25][CH2:26]2>>[CH3:1][N:2]([CH3:3])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C@H:17]1[CH2:34][C@@:32]2([CH3:33])[C@@H:28]([CH2:29][CH2:30][C@@H:31]2[OH:35])[C@@:27]2([CH:36]=[CH2:37])[C@H:18]1[C:19]1[CH:20]=[CH:21][C:22]([OH:38])=[CH:23][C:24]=1[CH2:25][CH2:26]2

Participants

4

Reactant 3

HCID 674DimethylamineHCID 10340Sodium CarbonateHCID 12137006HCID 12137006, compound

Product 1

HCID 12137008HCID 12137008, compound

Procedure

In the reaction with dimethylamine (2 M in tetrahydrofuran, 10 equivalents) with the addition of sodium carbonate analogously to instructions 17.2, 33 mg of mixture 30b yields 30 mg of amine 32b as a colorless foam (GC-MS: m/z theor.: 425, pract.: 425).

Sources & evidence

ORD record
ord-1042c9b8789647e9a68e0acbc4cfe810
Source dataset
uspto-grants-2008_05
Patent number
US07375098B2

Reaction notes

Loading…