反应详情

Sodium carbonate solution (10% aqueous, 30 ml) was added to a solution of 5-bromo-2-[3-(2,2,2-trichloro-ethanoyl)-ureido]-thiophene-3-carboxylic acid amide (1.0 g, 2.44 mmol) in EtOH (10 mL). The resulting reaction mixture was stirred under nitrogen overnight. After one third of the solvent was removed under vacuum, the reaction mixture was filtered. The precipitate was washed with water (3×50 mL) and dried in vacuum to give the above titled compound as a light brown solid (510 mg, 2.16 mmol, 89% yield).

1. customThe resulting reaction mixture
2. customAfter one third of the solvent was removed under vacuum
3. filtrationthe reaction mixture was filtered
4. washThe precipitate was washed with water (3×50 mL)
5. customdried in vacuum