2-amino-5-benzylthiophene-3-carboxamide → HCID 10424267, compound

HRID 2223360Notes

Reaction equation

HRID 2223360 reaction equation
NC1SC(CC2C=CC=CC=2)=CC=1[C:7]([NH2:9])=[O:8].[NH2:17][C:18]1[S:19][C:20]([CH:26]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH3:27])=[CH:21][C:22]=1[C:23]([NH2:25])=[O:24]>>[C:28]1([CH:26]([C:20]2[S:19][C:18]([NH:17][C:7]([NH2:9])=[O:8])=[C:22]([C:23]([NH2:25])=[O:24])[CH:21]=2)[CH3:27])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 38534572-amino-5-benzylthiophene-3-carboxamideHCID 220880943-Thiophenecarboxamide, 2-amino-5-(1-phenylethyl)-

Product 1

HCID 10424267HCID 10424267, compoundYield 87%

Procedure

5-(1-Phenyl-ethyl)-2-ureido-thiophene-3-carboxylic acid amide was prepared by the same procedure as Example 6b except that 2-amino-5-benzyl-thiophene-3-carboxylic acid amide was replaced with 2-amino-5-(1-phenyl-ethyl)-thiophene-3-carboxylic acid amide to give the above titled compound as a light brown solid (87% yield). LC-MS [M+H]+ m/z 290.

Sources & evidence

ORD record
ord-0f9a5019610d44c2bfb2228f9c180f3f
Source dataset
uspto-grants-2008_05
Patent number
US07375131B2

Reaction notes

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