Acetyl chloride → HCID 6852048, compound

HRID 2223362Notes

Reaction equation

HRID 2223362 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][C:6]1[S:7][CH:8]=[CH:9][C:10]=1[C:11]([NH2:13])=[O:12]>N1C=CC=CC=1>[C:1]([NH:5][C:6]1[S:7][CH:8]=[CH:9][C:10]=1[C:11]([NH2:13])=[O:12])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 6994952-Aminothiophene-3-carboxamide

Product 1

HCID 6852048HCID 6852048, compoundYield 97.2%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Acetyl chloride (4.2 mL, 59 mmol) was added dropwise to a solution of 2-amino-thiophene-3-carboxylic acid amide (7.7 g, 54.2 mmol) in pyridine (100 mL) at 0° C. The temperature of the reaction mixture was raised to room temperature over a 3 h period until no remaining starting material was present based on LC-MS. The solvent was then removed under vacuum to give the above titled compound as brown solid (9.7 g, 52.7 mmol, 97.2% yield). LCMS [M+H]]+ m/z 185.

Workup

  1. customThe solvent was then removed under vacuum

Sources & evidence

ORD record
ord-d11352bad41743d3918c7451b3a30985
Source dataset
uspto-grants-2008_05
Patent number
US07375131B2

Reaction notes

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