Diisopropyl Ether → HCID 178524395, compound

Participants

Reaction Steps

t-Butyl 4-{[(5-chloropyridin-2-yl)amino]carbonyl}-3-({[trans-4-(3-oxomorpholin-4-yl)cyclohexyl]carbonyl}amino)-benzoate (293 mg) obtained in Example 2 is dissolved in chloroform (10 ml), and thereto is added 4N hydrogen chloride-dioxane solution (10 ml) followed by stirring at room temperature for 3 days. To the reaction solution is poured diisopropyl ether, and the solid precipitates are collected by filtration to give the title compound (280 mg). ESI-MS M/Z: 499/501[M−H]−

Provenance & Evidence