Dimethylamine, hydrochloride → HCID 178484447, compound

Participants

Reaction Steps

4-{[(5-Chloropyridin-2-yl)amino]carbonyl}-3-({[trans-4-(3-oxomorpholin-4-yl)cyclohexyl]carbonyl}amino)benzoic acid (50 mg) obtained in Example 3 is dissolved in pyridine (1 ml), and thereto are added dimethylamine hydrochloride (20 mg), 1-hydroxybenzotriazole (27 mg) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (40 mg), followed by stirring at room temperature for 20 hours. To the reaction solution is poured saturated aqueous sodium hydrogen carbonate solution, and the mixture is extracted with chloroform. The organic layer is concentrated under reduced pressure, and the resulting residue is purified by NH-silica gel column chromatography (eluent: n-hexane/ethyl acetate=1/1, then ethyl acetate) to give the title compound (28 mg). APCI-MS M/Z: 528/530[M+H]+

Provenance & Evidence