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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2223608Generated: October 29, 2026

Ammonium Chloride → 4-[(4-{(1E)-2-[1-Carbamoyl-1-(methyl)-ethylcarbamoyl]vinyl}-2-methylphenyl)methyl]-3-(beta-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazole

https://huagongshe.com/reaction/2223608

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAmmonium ChlorideHCID 25517—
Reactant2-Amino-2-methylpropanamideHCID 6453783—
Reactant3-(2,3,4,6-Tetra-O-acetyl-beta-D-glucopyranosyloxy)-4-({4-[(1E)-2-carboxyvinyl]-2-methylphenyl}methyl)-5-isopropyl-1H-pyrazoleHCID 68537852—
Product4-[(4-{(1E)-2-[1-Carbamoyl-1-(methyl)-ethylcarbamoyl]vinyl}-2-methylphenyl)methyl]-3-(beta-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazoleHCID 68538156—

Reaction Steps

The title compound was prepared in a similar manner to that described in Example 26 using 3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)-4-({4-[(1E)-2-carboxyvinyl]-2-methylphenyl}methyl)-5-isopropyl-1H-pyrazole and 2-amino-2-methylpropionamide instead of 3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)-4-({4-[(1E)-3-carboxyprop-1-enyl]-phenyl}methyl)-5-isopropyl-1H-pyrazole and ammonium chloride, respectively.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07375087B2
Source datasetuspto-grants-2008_05
ORD IDord-e9d11e53711944ba87b61f9eff797a1d
Source noteuspto-grants-2008_05