HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 3-(beta-D-Glucopyranosyloxy)-5-isopropyl-4-[(4-{(1E)-2-[2-(sulfamoylamino)ethylcarbamoyl]vinyl}-2-methylphenyl)-methyl]-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | [(2-Aminoethyl)sulfamoyl]amine | HCID 23077839 | — |
| Reactant | 3-(2,3,4,6-Tetra-O-acetyl-beta-D-glucopyranosyloxy)-4-({4-[(1E)-2-carboxyvinyl]-2-methylphenyl}methyl)-5-isopropyl-1H-pyrazole | HCID 68537852 | — |
| Product | 3-(beta-D-Glucopyranosyloxy)-5-isopropyl-4-[(4-{(1E)-2-[2-(sulfamoylamino)ethylcarbamoyl]vinyl}-2-methylphenyl)-methyl]-1H-pyrazole | HCID 68537662 | — |
Reaction Steps
The title compound was prepared in a similar manner to that described in Example 26 using 3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)-4-({4-[(1E)-2-carboxyvinyl]-2-methylphenyl}methyl)-5-isopropyl-1H-pyrazole and N-sulfamoylethylenediamine instead of 3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)-4-({4-[(1E)-3-carboxyprop-1-enyl]phenyl}methyl)-5-isopropyl-1H-pyrazole and ammonium chloride, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07375087B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-ec182a248eff48408538c7242af601fd |
| Source note | uspto-grants-2008_05 |