HRID2223638

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)OC[C@H]1O[C@@H](Oc2n[nH]c(C(C)C)c2Cc2ccc(OCCC(=O)NC(C)(C)C(=O)OCc3ccccc3)cc2C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O

HCID68535991

未命名化合物

PRODUCTS

生成物

结构：CC(=O)OC[C@H]1O[C@@H](Oc2n[nH]c(C(C)C)c2Cc2ccc(OCCC(=O)NC(C)(C)C(=O)O)cc2C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O

HCID68535796

未命名化合物

收率 97.3%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID178418390

未命名化合物

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

3-(2,3,4,6-Tetra-O-acetyl-β-D-glucopyranosyloxy)-4-[(4-{2-[1-benzyloxycarbonyl-1-(methyl)-ethylcarbamoyl]ethoxy}-2-methylphenyl)methyl]-5-isopropyl-1H-pyrazole (0.15 g) was dissolved in methanol (5 mL). To the solution was added 10% palladium-carbon powder (50 mg), and the mixture was stirred at room temperature under a hydrogen atmosphere overnight. The insoluble material was removed by filtration, and the solvent of the filtrate was removed under reduced pressure to give the title compound (0.13 g).

WORKUP

后处理

customThe insoluble material was removed by filtration
customthe solvent of the filtrate was removed under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-56b2742f15714101ba2be69909ecaa36
来源数据集: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07375087B2
来源说明: uspto-grants-2008_05

反应 SMILES

[C:1]([O:4][C@@H:5]1[C@@H:10]([O:11][C:12](=[O:14])[CH3:13])[C@H:9]([O:15][C:16](=[O:18])[CH3:17])[C@@H:8]([CH2:19][O:20][C:21](=[O:23])[CH3:22])[O:7][C@H:6]1[O:24][C:25]1[C:29]([CH2:30][C:31]2[CH:36]=[CH:35][C:34]([O:37][CH2:38][CH2:39][C:40](=[O:55])[NH:41][C:42]([C:45]([O:47]CC3C=CC=CC=3)=[O:46])([CH3:44])[CH3:43])=[CH:33][C:32]=2[CH3:56])=[C:28]([CH:57]([CH3:59])[CH3:58])[NH:27][N:26]=1)(=[O:3])[CH3:2]>CO.[C].[Pd]>[C:1]([O:4][C@@H:5]1[C@@H:10]([O:11][C:12](=[O:14])[CH3:13])[C@H:9]([O:15][C:16](=[O:18])[CH3:17])[C@@H:8]([CH2:19][O:20][C:21](=[O:23])[CH3:22])[O:7][C@H:6]1[O:24][C:25]1[C:29]([CH2:30][C:31]2[CH:36]=[CH:35][C:34]([O:37][CH2:38][CH2:39][C:40](=[O:55])[NH:41][C:42]([C:45]([OH:47])=[O:46])([CH3:43])[CH3:44])=[CH:33][C:32]=2[CH3:56])=[C:28]([CH:57]([CH3:59])[CH3:58])[NH:27][N:26]=1)(=[O:3])[CH3:2]