Sodium Hydroxide → HCID 59583666, compound

Participants

Reaction Steps

A mixture of methyl 2-[({1-[(3,4-dichlorophenyl)methyl]-5-methyl-1H-1,2,3-triazol-4-yl}carbonyl)amino]-1,3-thiazole-5-carboxylate (Example 4) (0.403 g, 0.95 mmol) and a 1N NaOH solution (10 mL, 9.5 mmol) in EtOH was stirred at reflux for 2 hours. The solvent was evaporated and the residue was acidified with a 1N HCl solution. The precipitate formed was filtered and dried to give the title compound as a white solid (326 mg, 83%). LC/MS: m/z 412 (M+H)+. Rt: 2.48 min.

Provenance & Evidence