HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2223691Generated: November 2, 2026
2-Naphthylalanine → (1-{2-[3-(2-Methyl-quinolin-4-yl)-ureido]-ethyl}-piperidin-4-yl)-carbamic acid tert-butyl ester
https://huagongshe.com/reaction/2223691
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Naphthylalanine | HCID 185915 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| Reactant | 1-(2-Chloroethyl)-3-(2-methylquinolin-4-yl)urea | HCID 2344366 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (1-{2-[3-(2-Methyl-quinolin-4-yl)-ureido]-ethyl}-piperidin-4-yl)-carbamic acid tert-butyl ester | HCID 59715916 | — |
Reaction Steps
A mixture of piperidin-4-yl-carbamic acid tert-butyl ester (10 mmol), 1-(2-chloro-ethyl)-3-(2-methyl-quinolin-4-yl)-urea (10 mmol), NaHCO3 (20 mmol), Nal (0.5 mmol), and THF (70 mL) is stirred in a sealed vessel at 70° C. for 6 d. The reaction mixture is filtered, evaporated to dryness, and the residue is purified by preparative HPLC to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07375227B2 |
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| Source dataset | uspto-grants-2008_05 |
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| ORD ID | ord-a571f43b89834324a82189bc1c579112 |
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| Source note | uspto-grants-2008_05 |
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