関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Phenoxypiperidine | HCID 18878 | — |
| 反応物 | 2-Naphthylalanine | HCID 185915 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 1-(2-Chloroethyl)-3-quinolin-4-yl-urea | HCID 22643398 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | HCID 17956588 | HCID 17956588 | — |
反応手順
To a solution of 4-phenoxy-piperidine (0.03 mmol) in dry THF (1 mL) is added 1-(2-chloro-ethyl)-3-quinolin-4-yl-urea (0.03 mmol), solid NaHCO3 (2.5 mg), and Nal (1 mg). The flask is tightly sealed, and shaken at 70° C. for 6 days. The reaction mixture is evaporated, taken up in aqueous formic acid, and purified by preparative HPLC to provide the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07375227B2 |
|---|
| 出典データセット | uspto-grants-2008_05 |
|---|
| ORD ID | ord-d9c785a29f3a4bd9947f7673878c5dc4 |
|---|
| 出典メモ | uspto-grants-2008_05 |
|---|
