関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 4-(2-Methoxyphenyl)piperidine | HCID 544738 | — |
| 反応物 | 1-(2-Chloroethyl)-3-quinolin-4-yl-urea | HCID 22643398 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-{2-[4-(2-Methoxy-phenyl)-piperidin-1-yl]-ethyl}3-(2-methyl-quinolin-4-yl)-urea | HCID 59715922 | — |
反応手順
To a solution of 4-(2-methoxy-phenyl)-piperidine (0.03 mmol) in dry THF (1 mL) is added 1-(2-chloro-ethyl)-3-quinolin-4-yl-urea (0.03 mmol), solid NaHCO3 (2.5 mg), and NaI (1 mg). The flask is tightly sealed, and shaken at 70° C. for 6 days. The reaction mixture is evaporated, taken up in aqueous formic acid, and purified by preparative HPLC to provide the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07375227B2 |
|---|
| 出典データセット | uspto-grants-2008_05 |
|---|
| ORD ID | ord-c0ea3cda6dd04733a0615f3984c9d838 |
|---|
| 出典メモ | uspto-grants-2008_05 |
|---|
