HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-4-(4-methylphenyl)piperidin-4-ol → 4-(p-Tolyl)piperidin-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-4-(4-methylphenyl)piperidin-4-ol | HCID 198608 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-(p-Tolyl)piperidin-4-ol | HCID 93912 | — |
Reaction Steps
A mixture of 1-benzyl-4-p-tolyl-piperidin-4-ol (350 mg, 1.243 mmol), and Pd—C 10% (55 mg) in EtOAc (7 mL) is hydrogenated at room temperature and atmospheric pressure for 20 h. The mixture is filtered over Celite, and the filtrate is evaporated to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07375227B2 |
| Source dataset | uspto-grants-2008_05 |
| ORD ID | ord-c6f70b010c7a40709af899d864980563 |
| Source note | uspto-grants-2008_05 |