HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2223708Generated: October 26, 2026
4-(p-Tolyl)piperidin-4-ol → 1-[2-(4-Hydroxy-4-p-tolyl-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea
https://huagongshe.com/reaction/2223708
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-(p-Tolyl)piperidin-4-ol | HCID 93912 | — |
| Reactant | 2-Naphthylalanine | HCID 185915 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 1-(2-Chloroethyl)-3-(2-methylquinolin-4-yl)urea | HCID 2344366 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[2-(4-Hydroxy-4-p-tolyl-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea | HCID 17956568 | — |
Reaction Steps
To a solution of 4-p-tolyl-piperidin-4-ol (0.03 mmol) in dry THF (1 mL) is added 1-(2-chloro-ethyl)-3-(2-methyl-quinolin-4-yl)-urea (0.03 mmol), solid NaHCO3 (2.5 mg), and Nal (1 mg). The flask is tightly sealed, and shaken at 70° C. for 6 days. The reaction mixture is evaporated, taken up in aqueous formic acid, and purified by preparative HPLC to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07375227B2 |
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| Source dataset | uspto-grants-2008_05 |
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| ORD ID | ord-5d955996203d47a9ae7fd01ecd32c7c1 |
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| Source note | uspto-grants-2008_05 |
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