Propylphosphonic anhydride → HCID 59715927, compound

Participants

Reaction Steps

A suspension of (3-quinolin-4-yl-ureido)-acetic acid hydrochloride (281.7 mg, 1 mmol), 4-(3-methyl-benzylidene)-piperidine (187.3 mg, 1 mmol), TEA (1 mL, 7 mmol) in DMF (4 mL) and T3P (50% in EtOAc, 1 mL, 1.7 mmol) is stirred for 2 h at room temperature. The DMF is evaporated, the residue dissolved in CH2Cl2 (150 mL) and washed with 1M aqueous NaOH (50 mL) and brine (30 mL). The organic phase is dried (Na2SO4), filtered and evaporated to provide the crude title compound.

Provenance & Evidence