Ethyl Acetate → HCID 59715933, compound

Participants

Reaction Steps

To a suspension of LiAlH4 (100 mg, 2.6 mmol) in THF (40 mL) is added a solution of crude 1-{2-[4-(3-methyl-benzylidene)-piperidin-1-yl]-2-oxo-ethyl}3-(2-methyl-quinolin-4-yl)-urea (1 mmol) in THF (10 mL) and the mixture is stirred at room temperature for 15 h. The suspension is poured slowly into EtOAc (200 mL) and MeOH (10 mL) and, subsequently, sat. NaHCO3 (dropwise, total of 1.5 mL) is added. The precipitate is filtered off and washed with MeOH (2×20 mL). The filtrate is dried (Na2SO4), filtered and evaporated. The residue is purified by flash chromatography (SiO2, CH2Cl2-MeOH, 10:1) to provide the title compound.

Provenance & Evidence