N-Methylaniline → HCID 59715920, compound

Participants

Reaction Steps

To a suspension of 1-{2-[3-(2-methyl-quinolin-4-yl)-ureido]-ethyl}-piperidine-4-carboxylic acid dihydrochloride (64.25 mg, 0.15 mmol), TEA (0.07 mL, 0.5 mmol) and N-methylaniline (11 mg, 0.1 mmol) in DMF (0.6 mL) is is added T3P (50% in EtOAc, 0.07 mL, 0.12 mmol) at room temperature. The mixture is stirred for 15 h, quenched with sat. Na2CO3 (5 mL) and extracted with CH2Cl2 (3×10 mL). The organic phases are dried (Na2SO4), filtered, evaporated and the residue purified by preparative HPLC to provide the title compound.

Provenance & Evidence