Dimethylformamide → HCID 58612418, compound

Participants

Reaction Steps

1-(3-tert-Butyl-5-chloro-4-hydroxyphenyl)ethanone (1.65 g, 7.28 mmol) and methyl iodide (2.07 g, 14.56 mmol) were added to N,N-dimethylformamide (2.5 mL), followed by stirring on ice, and addition of potassium carbonate (1.51 g, 10.92 mmol). After 3 hours of stirring, toluene (30 mL) and water (20 mL) were added, and the solution was separated. The organic layer was washed with water (15 mL), dried, and then concentrated under reduced pressure (50° C.) to obtain 1.37 g of the subject compound as a yellowish oily substance (yield: 78.2%, HPLC purity: 99.4%)

Provenance & Evidence