Methanol → HCID 58612420, compound

Participants

Reaction Steps

Methanol (1.4 mL), and trimethyl orthoformate (1.79 g, 16.95 mmol) were added to 1-(3-tert-butyl-5-chloro-4-methoxyphenyl)ethanone (1.36 g, 5.65 mmol), followed by stirring at room temperature. In addition, (±)-10-camphorsulfonic acid [(±)-CSA] (65 mg, 0.282 mmol, 5 mol %) was added, followed by 2 hours of stirring. Potassium carbonate (156 mg, 1.128 mmol) was added. After 40 minutes of stirring, water (10 mL) and n-heptane (10 mL) were added, and the solution was separated. After washing the organic layer with water (10 mL), the solvent was evaporated (50° C.) to obtain 1.57 g of the subject compound as a yellow oily substance (yield: 96.9%).

Provenance & Evidence