Trifluoroacetic acid → HCID 11324510, compound

Participants

Reaction Steps

Trifluoroacetic acid (2.5 mL) was added in one portion to a stirred solution of 1,1-dimethylethyl N-{4-[(3-methylbutyl)oxy]phenyl}-N-(methylsulfonyl)glycinate (intermediate 7, 140 mg, 0.378 mmol) in dichloromethane (5 mL) at room temperature under an atmosphere of nitrogen. The resulting mixture was stirred for 3 h then the volatiles evaporated. A portion of the crude orange product was purified by reverse phase mass directed preparative HPLC to give the title compound as a white solid (20 mg). LC/MS: 3.22 min; z/e 333, calcd (M+18) 333. 1H NMR (400 MHz; MeOD): 0.95 (6H), 1.75 (2H), 1.85 (1H), 3.05 (3H), 4.05 (2H), 4.35 (2H), 6.90 (2H), 7.40 (2H).

Provenance & Evidence