Cyclohexanediacetic acid → 1,1-Cyclohexanediacetic Anhydride

Participants

Reaction Steps

A solution of 1,1-cyclohexane diacetic acid (20.0 g) in acetic anhydride (20 mL) was heated under reflux for 5 hours. The solution was concentrated under reduced pressure, and the residue was concentrated three times azeotropically with benzene. The resulting residue was purified by column chromatography (silica gel, hexane:ethyl acetate=2:1) to give the title compound (20.1 g).

Provenance & Evidence