Methanol → HCID 23021101, compound

Participants

Reaction Steps

To a solution of 1-(2-bromoethyl)cyclohexylacetic acid (4.98 g) in methanol (50 mL) was added thionyl chloride (1.76 mL) dropwise under ice cooling. After completion of the dropwise addition, the reaction solution was stirred for 18 hours, while its temperature was allowed to rise to room temperature. The reaction solution was concentrated under reduced pressure, and ethyl acetate was added to the resulting residue. The solution was washed in turn with saturated aqueous sodium bicarbonate solution, water and saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate and filtered. The filtrate was then concentrated under reduced pressure to give the title compound (5.41 g). This product was subjected to the subsequent step without further purification.

Provenance & Evidence