反应详情

6.1 700 mg of tert-butyl 3,5-diaminoindazole-1-carboxylate (3.1 mmol) and 532 mg of 1-(2-isocyanatoethyl)-3-methoxybenzene (3.0 mmol) are stirred at RT for 24 hours in 10 ml of dichloromethane. The reaction mixture is washed with water, the organic phase is separated off, dried and evaporated. Purification of the residue by column chromatography (eluent:ethyl acetate) gives 700 mg of tert-butyl-3-amino-5-{3-[2-(3-methoxyphenyl)ethyl]ureido}indazole-1-carboxylate (53%), MS-FAB (M+H+)=426.

1. washThe reaction mixture is washed with water
2. customthe organic phase is separated off
3. customdried
4. customevaporated
5. customPurification of the residue by column chromatography (eluent:ethyl acetate)