Triethyl ethane-1,1,2-tricarboxylate → Diethyl 2-[2-[1-[2(tert-butyldiphenylsiloxy)ethyl]cyclohexyl]ethyl]-2-ethoxycarbonylsuccinate

HRID 2223864Notes

Reaction equation

HRID 2223864 reaction equation
[C:1]([Si:5]([O:18][CH2:19][CH2:20][C:21]1([CH2:27][CH2:28]I)[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)([CH3:4])([CH3:3])[CH3:2].[CH:30]([C:42]([O:44][CH2:45][CH3:46])=[O:43])([C:37]([O:39][CH2:40][CH3:41])=[O:38])[CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33]>>[O:18]([CH2:19][CH2:20][C:21]1([CH2:27][CH2:28][C:30]([C:37]([O:39][CH2:40][CH3:41])=[O:38])([CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])[C:42]([O:44][CH2:45][CH3:46])=[O:43])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)[Si:5]([C:1]([CH3:2])([CH3:4])[CH3:3])([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 81961Triethyl ethane-1,1,2-tricarboxylateHCID 59714983Tert-butyl[2-[1-(2-iodoethyl)cyclohexyl]ethoxy]diphenylsilane

Product 1

HCID 59714909Diethyl 2-[2-[1-[2(tert-butyldiphenylsiloxy)ethyl]cyclohexyl]ethyl]-2-ethoxycarbonylsuccinateYield 65.8%

Procedure

Using tert-butyl-[2-[1-(2-iodoethyl]cyclohexyl]ethoxy]diphenylsilane (1.77 g) and triethyl 1,1,2-ethanetricarboxylate (2.51 g), the title compound (1.43 g) was obtained in the same manner as in Preparation Example 3B-1. This product was subjected to the subsequent step without further purification.

Sources & evidence

ORD record
ord-b534cb28c74f46419cc539b644c13bd3
Source dataset
uspto-grants-2008_05
Patent number
US07375115B2

Reaction notes

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