Water → HCID 59714837, compound

Participants

Reaction Steps

To a solution of dimethyl 2-[2-[1-[2-(tert-Butyldiphenylsiloxy)ethyl]cyclohexyl]ethyl]-2-pent-4-enylmalonate (910 mg) in diethyl ether (15 mL) was added lithium aluminum hydride (117 mg) under ice cooling. After stirring the solution at room temperature for 1 hour, water (0.12 mL) and a 15% aqueous sodium hydroxide solution (0.12 mL) were successively added thereto. The solution was stirred at room temperature for 15 minutes. Water (0.36 mL) was then added and the solution was stirred at room temperature for additional 15 minutes. The solution was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting residue was purified by chromatography (silica gel, hexane:ethyl acetate=6:4) to give the title compound (640 mg).

Provenance & Evidence