反应详情

6.2 700 mg of tert-butyl-3-amino-5-{3-[2-(3-methoxyphenyl)ethyl]-ureido}indazole-1-carboxylate (1.6 mmol) are stirred for 16 hours with 10 ml of HCl/dioxane (4 M). The batch is concentrated and evaporated three times with 10 ml of toluene each time in a rotary evaporator. The residue is purified by column chromatography on silica gel (eluent: dichloromethane:methanol 9:1). Drying gives 120 mg of “A20” (22%), MS-FAB (M+H+)=326,

1. concentrationThe batch is concentrated
2. customevaporated three times with 10 ml of toluene each time
3. customin a rotary evaporator
4. customThe residue is purified by column chromatography on silica gel (eluent: dichloromethane:methanol 9:1)
5. customDrying
6. customgives 120 mg of “A20” (22%), MS-FAB (M+H+)=326