1,3-Bis(diphenylphosphino)propane → HCID 23021225, compound

Participants

Reaction Conditions

Reaction Steps

2-Bromo-5-methylpyridine (8.56 g), 1,3-bis(diphenylphosphino)propane (4.10 g) and sodium tert-butoxide (6.69 g) were suspended in toluene (500 mL), to which was added ethyl 4-amino-1-piperidinecarboxylate (10.28 g). Tris(dibenzylideneacetone)dipalladium (3.19 g) was added to the suspension, and it was stirred at 70° C. for 4 hours. Ethyl acetate was added to the reaction solution, and then, it was washed with saturated aqueous sodium chloride solution, and dried (MgSO4). The solvent was distilled off under reduced pressure. The resulting residue was purified by chromatography (silica gel, ethyl acetate), and then crystallized (ethyl acetate/hexane) to give the title compound (10.13 g).

Provenance & Evidence