Dichloromethane → 1-(3-Cyclohexylpropyl)-4-(p-toluidino)piperidine

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(p-toluidino)piperidine trifluoroacetate (0.7726 g) dissolved in N,N-dimethylformamide (10 mL) were added (3-bromopropyl)cyclohexane (0.57 g) and potassium carbonate (1.02 g). The reaction solution was heated with stirring at 80° C. for 5 hours. Dichloromethane was added to the reaction solution, and the insolubles were filtered off, and then, the solvent was distilled off under reduced pressure. The resulting residue was purified by chromatography [silica gel, dichloromethane-methanol-aqueous ammonia (95:5:0.3)] to give the title compound as a while solid (0.4879 g).

Provenance & Evidence