Lithium Hydroxide → HCID 59715044, compound

Participants

Reaction Steps

To a solution of triethyl 3-[1-[2-[4-[N-(5-methylpyridin-2-yl)-2-furancarboxamido]piperidin-1-yl]ethyl]cyclohexyl]-1,1,1-propanetricarboxylate (200 mg) in 1,4-dioxane (9 mL) and water (3 mL) was added lithium hydroxide (100 mg). After stirring the solution at room temperature for 7 hours, water was added thereto and it was concentrated under reduced pressure. Acetic acid (0.14 mL) was added to the residue, and the solution was further concentrated under reduced pressure and to dryness. The residue was purified by chromatography (DIAION HP20 manufactured by Mitubishi Chemical Corporation, methanol) to give the title compound (150 mg).

Provenance & Evidence