1,4-Dioxane hydrochloride → HCID 25010224, compound

Participants

Reaction Steps

7.2 90 mg of tert-butyl 3-(3-chlorobenzoylamino)-5-[3-(2,5-difluorobenzyl)ureido]indazole-1-carboxylate are stirred for 16 hours with 3 ml of HCl/dioxane (4 M). The batch is evaporated and dried well. Purification of the residue by column chromatography on silica gel (eluent:heptane/EA 9:1) gives 23 mg of 1-[3-(3-chlorobenzoylamino)-1H-indazol-5-yl]-3-(2,5-difluorobenzyl)urea (“A21”) as a colourless powder (31%), MS-FAB (M+H+)=456;

Provenance & Evidence