Hydrochloric Acid → HCID 59714883, compound

Participants

Reaction Steps

To a solution of N-[1-[2-[1-(2-phenyl-1,3-dioxan-5-yl)cyclohexyl]ethyl]piperidin-4-yl]-N-(5-methylpyridin-2-yl)-2-furancarboxamide (110 mg) in methanol (5 mL) was added 4N hydrochloric acid (0.5 mL). After stirring the solution at room temperature for 2 hours, it was concentrated under reduced pressure. Saturated aqueous sodium bicarbonate solution was added to the residue and it was extracted with chloroform. The combined organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the title compound. To a solution of the residue in ethyl acetate (10 mL) was added a 4N hydrochloric acid/ethyl acetate solution (0.15 mL), and the solution was stirred at room temperature for 1 hour. The crystals thus separated out were then filtered to give its hydrochloride (60 mg).

Provenance & Evidence