Ammonium Chloride → HCID 59714851, compound

Participants

Reaction Steps

[1-[2-[4-[N-(5-Methylpyridin-2-yl)-2-furancarboxamido]piperidin-1-yl]ethyl]cyclohexyl]acetic acid (909 mg), ammonium chloride (216 mg), benzotriazol-1-yloxytrispyrrolidinophosphonium hexafluorophosphate (1.56 g), 1-hydroxybenzotriazole hydrate (470 mg) and N,N-diisoprpoylamine (1.4 mL) were dissolved in N,N-dimethylformamide (8 mL). The solution was stirred at room temperature for 22 hours. Saturated aqueous sodium bicarbonate solution was added to the solution, and it was extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate, filtered, and then, the solvent was distilled off under reduced pressure. The resulting residue was purified by chromatography (silica gel, chloroform:methanol=10:1) to give the title compound (652 mg).

Provenance & Evidence