Trifluoroacetic acid → HCID 10162177, compound

Participants

Reaction Steps

To tert-butyl [1-[2-[4-[N-(5-methylpyridin-2-yl)-2-furancarboxamido]piperidin-1-yl]ethyl]cyclohexyl]acetohydroxamate (266 mg) was added trifluoroacetic acid (3.0 mL), and the solution was stirred at room temperature for 23 hours. The solution was then stirred at 40° C. for 2 hours and trifluoroacetic acid (2.0 mL) was further added. The solution was stirred at 50° C. for 3 hours. The trifluoroacetic acid was distilled off by azeotropic distillation with xylene. Water and chloroform were added to the residue and the solution was neutralized with saturated aqueous sodium hydrogencarbonate solution. The solution was extracted with 20% ethanol/chloroform. The organic layer was dried over anhydrous magnesium sulfate, filtered, and then, the solvent was distilled off under reduced pressure. The resulting residue was purified by chromatography (silica gel, chloroform:methanol=85:15) to give the title compound (75 mg).

Provenance & Evidence