Dicyclohexylcarbodiimide → HCID 10280007, compound

Participants

Reaction Steps

[1-[2-[4-[N-(p-Tolyl)-2-furancarboxamido]-piperidin-1-yl]ethyl]cyclohexyl]acetic acid (synthesized in Example 3B-1) (203 mg), methanesulfonamide (84 mg), 1,3-dicyclohexylcarbodiimide (101 mg) and 4-dimethylaminopyridine (59 mg) were dissolved in dichloromethane (5 mL). The solution was stirred at room temperature for 4 days. The reaction solution was concentrated under reduced pressure. The resulting residue was purified by chromatography [silica gel, dichloromethane-methanol (10:1)] to give the title compound (233 mg).

Provenance & Evidence