1,4-Dioxane hydrochloride → HCID 23109894, compound

Participants

Reaction Steps

To a solution of tert-butyl 2-[1-[2-[4-[N-(p-tolyl)-2-furancarboxamido]piperidin-1-yl]ethyl]cyclohexyl]ethylcarbamate (synthesized in Example 17) (1.14 g) in methanol (4 mL) was added a 4N hydrochloric acid/dioxane solution (3 mL). The solution was stirred at room temperature for 12 hours. The reaction solution was concentrated under reduced pressure. The resulting residue was purified by chromatography [NH silica gel, chloroform-methanol (20:1)] to give the title compound (1.01 g).

Provenance & Evidence