Sodium Hydroxide → HCID 59714839, compound

Participants

Reaction Steps

To a solution of dimethyl 5-[2-[1-[2-[4-[N-(p-tolyl)-2-furancarboxamido]piperidin-1-yl]ethyl]cyclohexyl]ethoxy]isophthalate (synthesized in Example 28) (255 mg) dissolved in methanol (5 mL) was added a 2N aqueous sodium hydroxide solution (2.0 mL). The solution was stirred at room temperature for 24 hours. The reaction solution was concentrated under reduced pressure. Water was then added to the solution, and it was neutralized with acetic acid (0.23 mL) and extracted with chloroform-ethanol (80:20). The organic layer was dried over anhydrous magnesium sulfate and filtered. The filtrate was then concentrated under reduced pressure to give the title compound (243 mg).

Provenance & Evidence