Hydrochloric Acid → HCID 59714877, compound

Participants

Reaction Steps

To a solution of methyl 2-[2-[1-[2-[4-[N-(p-tolyl)-2-furancarboxamido]piperidin-1-yl]ethyl]cyclohexyl]ethoxy]benzoate (synthesized in Example 39) (221 mg) in methanol (5 mL) was added a sodium hydroxide (77 mg) solution in water (3 mL) dropwise at room temperature. The solution was stirred for 18 hours. After neutralizing the reaction solution with 2N hydrochloric acid, silica gel was added to the solution. The solution was concentrated under reduced pressure. The resulting residue was purified by chromatography [silica gel, chloroform-methanol (10:1)] to give the title compound (172 mg).

Provenance & Evidence