Dichloromethane → HCID 69144794, compound

Participants

Reaction Steps

To a solution of N-[1-[2-[1-(2-aminoethyl)cyclohexyl]ethyl]piperidin-4-yl]-N-(5-methylpyridin-2-yl)-2-furancarboxamide (synthesized in Example 3F-5) (104 mg) and 1,3-bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea (85 mg) in N,N-dimethylformamide (5 mL) were added N,N-diisopropylethylamine (0.12 g) and then mercury (II) chloride (113 mg) at room temperature. The solution was stirred at room temperature for 3 days. Dichloromethane was added to the solution and insolubles were filtered off with Celite. The solvent was distilled off under reduced pressure. The resulting residue was purified by chromatography [silica gel, dichloromethane-methanol-aqueous ammonia (97:3:0.2)] to give the title compound (0.1049 g).

Provenance & Evidence