Hydrochloric Acid → HCID 59715050, compound

Participants

Reaction Conditions

Reaction Steps

To an ice-cooled solution of diisopropylamine (1.68 mL) in tetrahydrofuran (10 mL) was added 1.57 M n-butyllithium/hexane (7.0 mL) dropwise over 10 minutes. After stirring the reaction solution under ice cooling for additional 30 minutes, it was cooled to −78° C. and a solution of 2-(cyclobutylidene)ethyl acetate (1.96 g) in tetrahydrofuran (2 mL) was added thereto dropwise over 10 minutes. After stirring the reaction solution at that temperature for 1 hour, chiorotrimethylsilane (1.52 mL) was added dropwise over 5 minutes. The reaction solution was stirred at room temperature for 1 hour, and then, heated under reflux for 4.5 hours. The reaction solution was ice-cooled and methanol (5 mL) and a 3N aqueous sodium hydroxide solution (8 ml) were added. The solution was stirred for 30 minutes. Then, conc. hydrochloric acid (4 mL) was added to the solution and it was stirred for additional 30 minutes. The reaction solution was extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was dissolved in N,N-dimethylformamide (20 mL), to which potassium carbonate (8.29 g) and methyl iodide (1.87 mL) were added. The solution was stirred at room temperature for 3 hours. The reaction solution was filtered with Celite and insolubles on Celite were washed with ethyl acetate. The filtrate was combined with the wash and washed in turn with 2N hydrochloric acid and saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was purified by chromatography [silica gel, hexane-ethyl acetate (97:3)] to give the title compound (1.33 g).

Provenance & Evidence