Acetic Acid → HCID 131726891, compound

Participants

Reaction Steps

Into 7 mL of a solution of acetic acid, tetrahydrofuran, trifluoroacetic acid and water (3:1:0.4:1), 358.4 mg (378 μmol) of the compound (X) was dissolved. The solution was reacted at room temperature for 16 hours while stirring, and the reaction mixture was extracted with ethyl acetate (3×10 mL). The. organic layers were combined, washed with brine (2×20 mL), dried over anhydrous sodium sulfate, filtered, concentrated in vacuo, and purified by silica gel flash chromatography (dichloromethane methanol=10:1→dichloromethane:methanol:water=65:25:4) (yield: 138.1 mg (229 μmol), recovery: 62.7%).

Provenance & Evidence