HCID 69104771, compound → HCID 68657772, compound

Participants

Reaction Steps

A solution of 700 mg of 3-methoxy-8β-vinyl-estra-1,3,5(10)-trien-17β-ol in 30 ml of dichloromethane was mixed with 740 mg of pyridinium chlorochromate and stirred for 3 hours at room temperature. By filtration of the reaction mixture on silica gel (solvent mixture: cyclohexane/ethyl acetate=7/3) and subsequent concentration by evaporation of the filtrate in a rotary evaporator, 680 mg (98%) of 3-methoxy-8β-vinyl-estra-1,3,5(10)-trien-17-one was obtained as almost colorless foam, which was used in the next stage without further purification.

Provenance & Evidence